Please use this identifier to cite or link to this item: http://dspace.utpl.edu.ec/handle/123456789/19006
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMalagon Aviles, O.es_ES
dc.contributor.authorBailon Moscoso, N.es_ES
dc.date.accessioned2017-06-16T22:02:46Z-
dc.date.available2017-06-16T22:02:46Z-
dc.date.issued2015-01-01es_ES
dc.date.submitted01/06/2015es_ES
dc.identifierdoies_ES
dc.identifier.isbn15680266es_ES
dc.identifier.otherdoies_ES
dc.identifier.urihttp://dspace.utpl.edu.ec/handle/123456789/19006-
dc.description.abstractPhytochemical investigation of Azorella madreporica led to the isolation of four known compounds and an unknown chalcone. The structure of the new compound was identified by spectroscopy, including two-dimensional NMR techniques and comparison with published spectral data. The antioxidant activity of chalcone (compound 1) was measured using the 1,2-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay, and the bioactivity was evaluated against five bacteria (Mycobacterium smegmatis ATCC 14468, clinical isolates of Staphylococcus aureus, Klebsiella granulomatis, Morganella morganii and Escherichia coli) and four cancer cell lines. Docking studies with the tested cancer related proteins revealed nearby values of energy between doxorubicin and compound 1. Besides, protein-ligand interactions correlate with these energy values. © 2015, Bentham Science Publishers.es_ES
dc.languageIngléses_ES
dc.subjectAntitumorales_ES
dc.subjectAzorella madreporicaes_ES
dc.subjectChalconees_ES
dc.subjectDiterpeneses_ES
dc.subjectDockinges_ES
dc.subjectYaretaes_ES
dc.titleMolecular docking studies of the antitumoral activity and characterization of new chalconees_ES
dc.typeArticlees_ES
dc.publisherCurrent Topics in Medicinal Chemistryes_ES
Appears in Collections:Artículos de revistas Científicas

Files in This Item:
There are no files associated with this item.


This item is protected by original copyright



Los recursos publicados en el RiUTPL se distribuyen bajo la licencia: CreativeCommons