Estudio del gen ApoE en población lojana y su asociación a rasgos metabólicos.

Abstract

The Metabolic Syndrome (MS) is one of the leading causes of death in the world and is becoming more frequent in our country, it is a polygenic and multifactorial entity. In genetic-based studies, a group of susceptibility genes have been implicated, including the apolipoprotein E (ApoE) gene; this gene plays an important role in lipid metabolism, so the objective of this work was to know the frequencies it´s alleles and genotypes in the lojana population to later evaluate possible associations to metabolic traits. The allele frequency was 5.42%, 81.28% and 13.30% for ε2, ε3 and ε4, respectively, and genotype frequencies were 63.55% for ε3/ε3 genotype, 25.61% for ε3/ε4, 9.84% for ε2/ε3, and 0.5% for ε2/ε2 and ε4/ε4, the ε2/ε4 genotype was not found. The ε3 allele and the ε3/ε3 genotype were the most frequent in all the study population being similar to other studies worldwide, no association of these genotypes with MS was found, but there was a positive relation between ApoE polymorphisms and lipidic profile.