Estudio de genes GST en población lojana y su asociación a rasgos metabólicos

Abstract

The metabolic syndrome is a public health problem due to its high prevalence and risk of developing cardiovascular diseases and type 2 diabetes. Studies propose to oxidative stress as a trigger of metabolic diseases, consequently, study of regulatory genes of the cellular oxidative state is important. The enzymes glutathione S-transferase (GST) catalyze detoxifying reactions, and polymorphisms in genes encoding them, would generate decreased detoxification, increasing the risk in carriers of these polymorphisms, oxidative stress toxicity. The objective of the present study was to determine the frequency of null genetic polymorphisms GSTM1 and GSTT1 in the population from Loja, and its relation with metabolic syndrome. The frequency of null polymorphisms GSTM1 and GSTT1 in the studied population was 17.7 and 16.3%, respectively, and the combination of both polymorphisms null was 5.4%. A significant association was found between the null GSTM1 genotype with increased systolic blood pressure, decreased glucose in people with metabolic syndrome, and low levels of body mass index in people without metabolic syndrome; Likewise, a significant association between the null GSTT1 genotype with high waist-hip ratio values in people with metabolic syndrome.