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Title: Molecular docking studies of the antitumoral activity and characterization of new chalcone
Authors: Malagon Aviles, O.
Bailon Moscoso, N.
Keywords: Antitumoral
Azorella madreporica
Yareta 2017-06-16T22:02:46Z
Issue Date: 1-Jan-2015
Publisher: Current Topics in Medicinal Chemistry
Abstract: Phytochemical investigation of Azorella madreporica led to the isolation of four known compounds and an unknown chalcone. The structure of the new compound was identified by spectroscopy, including two-dimensional NMR techniques and comparison with published spectral data. The antioxidant activity of chalcone (compound 1) was measured using the 1,2-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay, and the bioactivity was evaluated against five bacteria (Mycobacterium smegmatis ATCC 14468, clinical isolates of Staphylococcus aureus, Klebsiella granulomatis, Morganella morganii and Escherichia coli) and four cancer cell lines. Docking studies with the tested cancer related proteins revealed nearby values of energy between doxorubicin and compound 1. Besides, protein-ligand interactions correlate with these energy values. © 2015, Bentham Science Publishers.
metadata.dc.identifier.other: doi
ISBN: 15680266
Other Identifiers: doi
Other Identifiers: doi
metadata.dc.language: Inglés
metadata.dc.type: Article
Appears in Collections:Artículos de revistas Científicas

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