Please use this identifier to cite or link to this item: http://dspace.utpl.edu.ec/jspui/handle/123456789/19253
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dc.contributor.authorMalagon Aviles, O.es_ES
dc.contributor.authorValarezo Valdez, B.es_ES
dc.contributor.authorTammaro, L.es_ES
dc.contributor.authorGonzalez Perez, S.es_ES
dc.contributor.authorVittoria, V.es_ES
dc.date.accessioned2017-06-16T22:03:13Z-
dc.date.available2012-12-20es_ES
dc.date.available2017-06-16T22:03:13Z-
dc.date.submitted17/01/2013es_ES
dc.identifierhttp://dx.doi.org/10.1016/j.clay.2012.12.006es_ES
dc.identifier.isbn1691317es_ES
dc.identifier.otherhttp://dx.doi.org/10.1016/j.clay.2012.12.006es_ES
dc.identifier.urihttp://dspace.utpl.edu.ec/handle/123456789/19253-
dc.description.abstractAmoxicillin (AMOX) was intercalated in layered double hydroxide (LDH) nanoparticles by coprecipitation. LDH intercalated with AMOX (LDH/AMOX) was successfully encapsulated at different concentrations into poly(?-caprolactone) (PCL) by the electrospinning technique. Mats of non-woven PCL fibers loaded with LDH/AMOX were obtained and characterized in terms of morphology and in vitro release. The fibrous structure of a pristine PCL sample was composed of individual, uniform, and randomly oriented fibers with an average diameter ranging around 0.8. ?m. The addition of LDH/AMOX at different concentrations caused a slight increase of the average diameter and the presence of rare beads possibly due to clusters of the nano-hybrid on the surface of the microfibers.The release curves present a sustained release behavior, although an initial rapid drug release was found. The initial high-rate drug release period was followed by a second step in which the release is slow, extending for long time. The comparison of the release curves showed that the release of AMOX protected into the clay is slower than the release of the drug alone. © 2012 Elsevier B.V.es_ES
dc.languageIngléses_ES
dc.subjectamoxicillines_ES
dc.subjectelectrospinninges_ES
dc.subjectfiberses_ES
dc.subjectlayered double hydroxidees_ES
dc.subjectpoly(caprolactone)es_ES
dc.titleFabrication and sustained release properties of poly(epsilon-caprolactone) electrospun fibers loaded with layered double hydroxide nanoparticles intercalated with amoxicillines_ES
dc.typeArticlees_ES
dc.publisherApplied Clay Sciencees_ES
Appears in Collections:Artículos de revistas Científicas



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