Manifestaciones clínicas y los métodos de diagnóstico de la trombofilia primaria

Abstract

Abstract:Hereditary thrombophilia is a primary hypercoagulable state, it presents an alteration in some genes that code for coagulation factors or for proteins that intervene in the inhibition of coagulation or in the fibrinolytic system. Objective: To describe theclinical manifestations and diagnostic methods of primary thrombophilia. Methodology: A bibliographic review of publications was carried out, identified in four databases: Cochrane, Google Scholar, PubMed, Wiley online library, and manual searches in scientific journals. Results: From a total of 11 articles analyzed, it was observed that primary thrombophilia predominates more in women, presenting spontaneous abortions with no apparent cause as the main manifestation, the most common clinical manifestationis deep vein thrombosis. Conclusion: Diagnostic tests for primary thrombophilia include the study of protein C and S, factor V Leyden, antithrombin III and the mutation of the G20210A gene. The most common clinical manifestations are thromboembolic episodes, venous thrombosis, pulmonary embolism and repeated abortions without apparent cause, presentedbefore the 50 years.