Revisión bibliográfica de la eficacia del tratamiento farmacológico en la neuropatía diabética y el impacto en la mejoría de la calidad de vida

Abstract

Abstract: Aim:To conduct a bibliographic review of the most effective pharmacological treatment used in the last 5 years in patients with diabetic neuropathy and the impact on the improvement of quality of life.Materials and methods:Search in databases such as Scopus, LILACS, PubMed, and Elsevier Science Direct, we found systematic reviews, multivariate analyses, randomized placebo-controlled clinical trials from 2015 on more effective pharmacological treatments for the management of diabetic neuropathy and their impact on the improvement of quality of life. In English and Spanish.Results:Fifteen clinical trials, systematic reviews and meta-analyses of oral, topical and intravenous drugs effective for the management of diabetic neuropathy were analyzed. The evidence suggests pregabalin, gabapentin and duloxetine as first-line drugs; there is a drug in phase III study that seems to be a good alternative. Conclusions: The most effective drugs for the treatment of diabetic neuropathy are pregabalin, gabapentin and duloxetine, without forgetting the use of coadjuvants that will reduce the pain of diabetic patients.