Bioinformática y minería de datos para la priorización de estrategias biotecnológicas en salud animal: Evaluación del caso Efecto pleiotrópico de la melanina sobre la patogénesis fúngica en bovinos

Abstract

Abstract: Fungi threaten public health, food biosecurity and biodiversity. Historically, we perceived animal mycoses as diseases of low prevalence. However, the incidence of mycosis has increased considerably in recent decades. The limited understanding of the mechanisms involved in fungal virulence is one of the main limitations to preventing and treating mycoses in cattle production. Melanin plays a relevant role in the pathogenesis of many of these mycoses. Fungal virulence factors and the relevance of melanin in the evasion of the bovine immune response were reviewed here. Based on exhaustive bibliographic searches and bioinformatic tools, an extensive list of references was obtained on the principal pathogenic fungi species that infect cattle, the most important fungal diseases, the 107 causative fungispeciesand the main virulence factors, including those in which melaninis involved. This synthesis can contribute to filling information gaps associated with this problem and lead to the proposal of biotechnological strategies that reduce the impacts of fungal mycoses in cattle.