Análisis de frecuencias alélicas de importancia clínica del gen APOE en población lojana

Abstract

Abstract:Genetic studies have been involved a group of susceptibility genes, including the apolipoprotein E. This gene plays an important role in lipid metabolism, and has been related to metabolic syndrome. This disease is one of the most important public health problems of the new century, considered by some authors as a global epidemic. Its prevalence worldwide is estimated between 10% and 40%. In Latin America, values of 27% are reported in Mexico and 40.2% in Bolivia; in Ecuador it is 27.7%. For this reason, the objective of this work is to analyze the allelic frequencies and the clinical importance of the APOE gene in the population of Loja. In our study, an allele frequency of 5.3% was found for ε2, 81.3% for the ε3 allele, and 13.4% for the ε4 allele; and the genotypic frequencies found were 0.5% for the ε2/ε2 genotype, 63.6% for ε3/ε3, 0.5% for ε4/ε4, 9.6% for ε3/ε2 and 25.8% for ε3/ε4; resulting in the ε3 allele with the highest prevalence in the population studied.