Estudios sobre derivados con base en N,N-13-dimetilamino - dehidroleucodin

Abstract

Abstract: Sesquiterpene lactones are a large group of molecules whose main function is to protect plants against predators. Initially it was established that their toxicity level was high, but through different scientific research studies it was confirmed that they could act as promising antitumor agents. studies confirmed that they could act as promising antitumor agents. In the case of dehydroleucodine, its structure contains a group called α-methylene--lactone, to which biological activity has been assigned, especially against acute myeloid leukemia. The compound has a limited solubility in water. In this work, studies were developed to modify 2ehydroleucodine at the structural level, obtaining as a result three derivatives, from which it was proposed to continue with the research on N,N-13-dimethylamino-dehydroleucodine. A methodology based on Luche's conditions was also proposed to reduce the carbonyl of position 2 of the cyclopentanone system. As a final result four compounds were obtained, of which two turned out to be N,N-13-dimethylamino-dehydroleucodine, while the third derivative due to its molecular weight was considered for future analysis, emphasizing the fourth compound it was possible to isolate 9.9 mg of: Lactol; 12-hydroxy-N,N-13-dimethylamino dehydroleucodine.