El uso de inhibidores de la bomba de protones y el riesgo de desarrollar osteoporosis

Abstract

Abstract: In recent years, the inappropriate use of proton pump inhibitors (PPIs) has increased and and various potential health risks are associated; one of them is bone involvement. The general objective of the present study is to review the biomedical literature for an updated description of the association of proton pump inhibitors as a risk factor for developing osteoporosis. A bibliographic research was carried out in the Pubmed database, PAHO Virtual Health Library, Springer Link and Science Direct, each of them using search equations through the terms Mesh: proton pump inhibitors, osteoporosis, osteoporotic fractures. According to the results, it is evident that there is a association between the use of proton pump inhibitors and the risk of developing osteoporotic fractures; however, the causal mechanism is not clearly known. In conclusion, the risk of developing osteoporosis increases when PPIs are used in gastrointestinal pathologies for a prolonged period 1 year.