Factores de crecimiento en el tratamiento de las úlceras de pie diabético

Abstract

Abstract: The diabetic foot constitutes the main complication of diabetes mellitus, being the ulcer the first presentation. Ulcers generate great limitations, reduce the daily functionality, causing dependency in patients. The conventional treatment of diabetic foot has not shown effective results in the wound closure period. HE It has been shown that growth factors facilitate complete closure and reduce the time of wound healing, in addition to reducing complications such as amputation. This Narrative literature review is executed to determine the effectiveness of these factors biological agents in the complementary treatment of diabetic foot ulcers, emphasizing find those that generate the greatest benefit, determine their mechanism of action and effect. A thorough search was carried out in Pubmed, Science Direct and Virtual Library in health (VHL), 10 articles were analyzed and corroborated the effectiveness of these factors by decrease wound healing time, reduce adverse effects and avoid the need of systemic drugs, with epidermal growth factor, platelet-derived growth and autologous platelet-rich plasma.