Estimulación del sistema inmune innato por vacunas: avances recientes en los mecanismos y efectividad de adyuvantes

Abstract

Abstract: One of the biggest unknowns of vaccination, and one that also represents a great challenge, is how to induce increasingly stronger and longer lasting antibody responses. In order to try to achieve the above, adjuvants began to be used, which are substances that modulate and amplify the quality of the immune system's response to an antigen. Vaccines seek above all to provoke a robust immune response by presenting the antigen in a sustained manner with the help of the adjuvant, and one of the most important functions of adjuvants is to allow a reduction in the dose of the immunogen to which the immune system must create said response. It is necessary to advance in the development of new adjuvants that allow a significant improvement in the magnitude and quality of the immune system's response. In this narrative review, a series of articles were analyzed, which allowed us to correlate and verify various pathways of action, chemical modifications, effects, induction of immune response and use of a series of adjuvants.