Ensayo de cierre de herida en líneas celulares de próstata tras la exposición a plaguicidas

Abstract

Abstract: Pesticides, chemical compounds widely used in agriculture for pest control, have been identified as a hazard, as they pose long-term problems for both the environment and human health; they can be found in the environment and even in food. It has been reported that pesticides cause toxicity, affecting different cellular processes such as cell death and various signaling pathways. This study focused on determining in vitro cellular alterations in PNT2 and PC3 cell lines exposed to pesticides through a wound healing assay, using different commercial pesticide formulations; the differences between treatments and the control were analyzed by analysis of variance (ANOVA). Significant differences were observed in the viability assay of the PNT2 cell line, where an increase in viability was observed at 48 hours, and no significant differences were observed in wound closure and migration rate. No significant differences were found in the analyses with the PC3 cell line.