Genes asociados con Síndrome de Guillain Barré en cepas de Campylobacter aislada de reservorios animales

Abstract

Abstract: Guillain Barré syndrome (GBS) is an autoimmune disease, which is related to many cases with a previous infection caused largely by Campylobacter jejuni which is normally found in warm-blooded animals, with chicken being the reservoir major. Through molecular studies of this bacteria, genes have been found specific ones like wlaN and cgtB that increase the chances of a response autoimmune because they are associated with the synthesis of type lipooligosaccharides (LOS). A, B and C. The same ones that are responsible for imitating the gangliosides of neurons such as GM1, GD1a, which is known as molecular mimicry, which facilitates development of the SGB. The objective of this study is to determine the prevalence of genes associated with Guillain Barré syndrome in C. jejuni strains isolated from animal reservoirs, using bibliographic review. A lower prevalence of C. jejuni strains has been observed associated with Guillan Barré syndrome in high-income countries compared to medium and low income, with birds being the main reservoir of strains with the wlaN and cgtB genes.