Genes asociados con Síndrome de Guillain Barré en cepas de Campylobacter aisladas de humanos

Abstract

Abstract: Guillain-Barré syndrome is an acute immune disorder that affects the immune system. highly strung. It can be caused by various factors, the most common being Campylobacter jejuni, associated with gastrointestinal infections. Some strains of this bacteria contain the wlaN and/or cgtB genes, which gives rise to molecular mimicry making the system immune system mistakenly attacks not only the bacteria but also the nervous system of the host. The objective of this study is to determine the prevalence of the wlaN and cgtB and its relationship with Guillain-Barré syndrome in Campylobacter strains isolated in humans. The results show that the greater prevalence of these genes will depend on the geographic region, with Switzerland being the country with the highest prevalence for both genes, and South Korea with the lowest prevalence for wlaN which fundamentally exposes the importance of epidemiological studies and prevention measures adapted to each local context. This study highlights the various opportunities to take into account to analyze the health surveillance present in the regions affected by this bacteria.