Aislamiento e identificación de metabolitos secundarios de la especie artemisia sodiroi hieron

Abstract

Abstract: The species Artemisia sodiroi Hieron, from the Asteraceae family, commonly known as ¨Wormwood¨, is used in traditional medicine in southern Ecuador for the treatment of stomach pains, headaches, coughs and also, women use it to regulate and control the menstrual period. In the present investigation, the phytochemical study is reported by means of column chromatography of three extracts (hexane, ethyl acetate and methanol) of the aerial parts of the species Artemisia sodiroi. From which five secondary metabolites were obtained, 24-methylenecycloartanol, stigmasterol, sitosterol, sabinyl acetate, and methyl-inositol. Their structures were elucidated by spectroscopic methods such as GC/MS, 1H MNR and 13C NMR. Additionally, the in vitro antimicrobial activity of the extracts of the Artemisia sodiroi species (methanol, hexane, ethyl acetate, butanol and water) were determined against six clinically isolated strains, including Staphylococcus aureus and Staphylococcus epidermiwÔdis, which present different profiles. of resistance to antibiotics. In this trial, the hexane extract, unlike the others, was the only one that showed low activity at high concentrations.