Estado de los receptores hormonales y marcadores inmunohistoquímicos en pacientes con cáncer de mama en el Instituto del cáncer SOLCA Loja, periodo 2010 al 2014

Abstract

This research aims to determine the hormone receptors and immunohistochemistry markers status, as well as identify the most frequent expression pattern and the relation between this pattern and the histological grade of the tumors of 103 female patients with breast cancer diagnosis, by reviewing the results of immunohistochemistry analysis, in SOLCA Loja Cancer Institute, in the period of 2010 through 2014. A descriptive, quantitative, cross-sectional and retrospective study was carried out.

It was determined that most patients with breast cancer shared epidemiological characteristics similar to those described in the literature. These include the female gender, aged 45 to 49 years old in 20.39%; urban residence in 75.73%. It was found that the most common histologic type is invasive ductal with 82.52%, followed by infiltrating lobular and papillary each by 2.91%; it was found that the highest percentage of patients with breast cancer express the subtype Luminal A with 40.78%, while the triple negative pattern (basal like) corresponds to a 19.42% and positive triple pattern (Luminal B) corresponds to 13.59%. It was also possible to identify the relation between histological grade and pattern of immunohistochemical expression is as follows: Luminal A predominantly related to G2 in 22.33%, Luminal B with G2 at a rate of 7.77%, as HER2 + with G2 in 11.65% and basal like with G3 at 12.62%.