Estudio del polimorfismo Pro12Ala del gen PPARG en la población lojana y su asociación a rasgos metabólicos.

Abstract

Metabolic syndrome is a non-transmissible, polygenic and multifactorial disease, whose presence significantly increases the risk of type 2 diabetes mellitus, coronary and cerebrovascular diseases, which are the main causes of death worldwide. The PPAR-G gene plays an important role in glucose and lipid homeostasis, so the aim of this work was to identify the Pro12Ala polymorphism of this gene, to determine the frequencies and to evaluate the relationship with metabolic syndrome or its related parameters in the local population. An allele frequency of 87.62% and 12.37% was found for 12Pro and 12Ala, respectively. The genotype frequencies found were 79.20% for Pro / Pro, 16.83% for Pro / Ala, and 3.96% for Ala / Ala, Pro allele and Pro / Pro genotype were the most frequent, similar to other studies worldwide. In this study, we found no association of the Pro12Ala polymorphism with metabolic syndrome, however, it was observed that carriers of the 12Ala allele have higher levels of LDL when compared to individuals of Pro / Pro genotype.