Determinación del daño genotóxico en población expuesta a material particulado MP 2,5 mediante ensayo de micronúcleos en la zona Sur de la ciudad de Cuenca – Ecuador.

Abstract

The present study aims to determine the damage genotoxic population exposed to high concentrations of material in particulate PM 2,5 using micronucleus test in the southwest of the city of Cuenca - Ecuador. The study involved 70 donors who reside or work in the area southwest of the city of Cuenca and are exposed to high and low concentrations of PM 2,5. Using the micronucleus test and the rest of the nuclear anomalies in buccal epithelial cells was determined the frequency of these 1000 cells. The descriptive statistics analysis for each group and analysis of the nonparametric tests using the test t - student using the statistical software Graphpad prism 5. The results showed genotoxic damage associated with exposure to high concentrations of PM 2,5 in the area southwest of the city of Cuenca, which represents a high risk of disease. In conclusion that exposed donors high concentrations of MP 2,5 are clearly genotoxic damage. These results with highly relevant in the determination of future studies.