Review del método para determinar Cannabinoides por GC-MS en pelo.

Abstract

Abstract:Cannabinoids are a group of substances originally found in the Cannabis plant. By means of the study of its pharmacokinetics it is observed that there are different ways of entering the organism. The cannabinoid (THC), is the main psychoactive of the cannabis plant; by its metabolization it is converted into (THC-COOH), Cannabidiol (CBD) and Cannabinol (CBN); the same ones that are analyzed in order to demonstrate the use of cannabis. It has been opting for different methods of analysis using conventional biological matrices: urine and blood, proving to have certain limitations. Hair proves to be the most suitable biological matrix for the analysis of different drugs of abuse, allowing a longer window of detection and retrospective analysis. The analytical methods exist several from immunoassays used as screening, chromatographic tests (immunoassays) and even gas chromatography coupled to a mass spectrometer, allowing the detection and quantification of even small amounts of cannabinoids and their metabolites. Due to their complexity, there are several analytical methods developed using gas chromatography-mass spectrometry (GC-MS) or in tandem (GC-MS / MS)