Optimización de la fórmula para un desinfectante de pisos a base del aceite esencial de Palo Santo (Bursera graveolens)

Abstract

Abstract: In this research, the formulation of a floor disinfectant using essential oil of palo Santo %XUVHUD JUDYHROHQV as active ingredient (API) was optimized. A 25-1 factorial design (Fractional) was used in the preformulation and formulation studies in order to optimize the disinfectant. From these studies, a stable formula with 7 excipients and the essential oil of palo santo was obtained. In addition, the determination of the degradation percentage of API in each mixture was quantified using Gas Chromatography coupled to Mass Spectrometry (GC-MS). The results showed a API degradation of 30%. Finally, the microbiological efficacy studies of the floor disinfectant showed that it had an antimicrobial activity against Micrococcus luteus at 2000µg/ml, Enterococcus faecali at 2000µg/ml, and antifungal activity against Candida albicans at 4000µg/ml. In conclusion, in this work was demonstrated that the most stable formula and thus the optimized formula was the one containing sodium lauryl sulfate as surfactant and citric acid as pH regulator, since this formulation was able to maintain a higher percentage of limonene while achieving an antimicrobial and antifungal activities.