Citotoxicidad de 22 derivados tipo 4,4'-(arilmetil)-bis-(1-fenil-3-metil-1H-pirazol-5oles) en líneas celulares tumorales humanas

Abstract

Abstract: Cancer is a pathology that takes people s lives worldwide every year, which is why, in the search for new compounds to treat it effectively, medicinal chemistry has designed, synthesized and developed biologically active drugs, such as pyrazole. This drug is an aromatic compound made up of two nitrogen atoms and three carbon atoms, which, among its various utilities (analgesics, anti-inflammatory, antipyretic, antimicrobial, antidepressant, antioxidant, antihyperlipidemic, antiangiogenic, antileishmanicides), its main effect is anti-tumoral. Thus 21 derivatives of type 4,4'-(arylmethyl)-bis-(1phenyl-3-methyl-1h-pyrazol-5oles) were studied in this research work, considering the human tumor cell line of colon cancer (RKO), which was exposed to different concentrations of a variety of pyrazolics derivatives (functional groups) through viability tests by MTS and its anti-proliferative capacity was determined. Moreover, the results highlighted its cytotoxic and possible cytostatic effect through a morphological analysis with a dose-dependent inhibitory concentration was established for each one of them, the emphasis being placed, on the following compounds: 2n (9.87 ± 1.13 μM), 2s (14.83 ± 1.04 μM), 2i (23.45 ± 1.06 μM) and 2r (23.59 ±1.04 μM)