Revisión sistemática sobre el efecto de agentes tóxicos ambientales en la salud humana, modulación por variantes genéticas

Abstract

Abstract:Pesticides and their impact on human health are a current problem and a global concern. Even though they have helped to control the spread of disease and plagues in the agricultural field; they have become a threat to the wellbeing of entire communities, and evidence has shown long term exposure to these compounds to be harmful at a cellular level and is a predisposing factor for chronic disease. Our genetic code contains information for a series of countermeasures to interact given the contact with foreign chemical substances. Among the most relevant, we have enzymatic mechanisms such as the superfamily of proteins cytochrome p450, glutathione s transferase, but also DNA repairing processes like X-ray repair cross-complementing protein 1 and X-ray repair cross-complementing protein 4. For this research we searched and reviewed scientific literature on the effects of pesticides on human health, highlighting the mechanisms of cellular response to the exposure to xenobiotics as well as the polymorphisms on the DNA sequences encoding these proteins and their overall effect on the susceptibility to these agents.