Determinación de parámetros bioquímicos como biomarcadores diagnósticos para COVID-19, en el Hospital General Riobamba del IESS

Abstract

Abstract: Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to claim the lives of thousands of people worldwide. The identification of laboratory biomarkers capable of assessing disease progression is essential to ensure timely treatment. The objective of this research was to determine the concentration of several biochemical markers at different stages of progression of COVID-19. Seventy-four patients with positive diagnosis for COVID-19 at the General Hospital Riobamba were analyzed. Blood samples were taken during the first, second and third week of disease evolution. Serum ferritin, C-reactive protein, D-dimer and procalcitonin concentrations were quantified. A significant difference (p<0.0001) was observed in the biochemical markers at the different times analyzed, which returned to normal once the infection was over. In conclusion The biochemical markers studied are sensitive and reliable parameters that allow evaluation of the clinical progression of COVID-19, which allows timely treatment in these patients.