Obtención de nuevos derivados semi-sintéticos de la limonina A para estudios de actividad biológica.

Abstract

Abstract: The evaluation of the biological activity of limonoids has confirmed theirpotential as antibacterial, antiviral and anti-inflammatory.Limonin (L-A) is one of the main limonoidsin citrus, a bitter, white and crystalline substance related to the bitterness of juices that is found in itsaglycone form, being non-polar andinsoluble in water. L-A was extracted from seeds of Citrus sinensis, that were dried, groundedand extractedin Soxhlet equipment, initially using 100% hexane to eliminate fatsand finally100% dichloromethane to isolate the compound.Recrystallization was performedby usingacetic acid.The purified fraction wasidentifiedaslimonin,according to espectralNuclear Magnetic Resonancedata(NMR).The reactions to which the L-A was subjected were: Basic hydrolysis that actedon the lactone groups producing a derivate named sodium salt of ring A lactone of limonoic acid. Reduction of the C-7 carbonyl, which resulted in the corresponding alcohol (limonol). Through the structural modification and production of derivatives, it is sought to enhance its biological activity(anti-feedant / anti-inflammatory)and generate favorable physicochemical properties(water solubility)for the use of the newcompounds.