Desarrollo de formulaciones tópicas a base de crisaborol

Abstract

Abstract: This research addresses the development of topical gel formulations based on crisaborole, for their potential application in the treatment of dermatological conditions such as atopic dermatitis and psoriasis, both chronic inflammatory skin diseases, in order to provide a versatile, safe, and effective alternative for these patients. To this end, the following methodology was implemented: preformulation studies to evaluate the solubility and compatibility of the active ingredient in the formulations; physicochemical characterization; stability studies; and drug release studies to ensure adequate skin penetration of the gels. As a result of this research work, four formulations were selected, which differ primarily in the type of polymer used in their composition; their appropriate physicochemical characteristics, along with their stability, and allowed for adequate drug release. However, it is necessary to consider possible changes in the composition of the formulations, which will improve the physical and chemical stability of the gels over a longer period of time.