Inhibición del crecimiento de células tumorales de mama a partir de mezclas de extractos de semillas de zambo (Cucurbita ficifolia), almendras (Prunus dulcis) y nuez de macadamia (Macadamia integrifolia)

Abstract

Abstract: Breast cancer is the most common cancer diagnosis in women in Latin America, associated with factors such as hormonal changes, oral contraceptives, overweight, alcohol and tobacco use, and family history. This study evaluated the effects of extracts of Prunus dulcis with Cucurbita ficifolia and Macadamia integrifolia with Cucurbita ficifolia on cancer cells. The extracts showed a dose-dependent effect: at concentrations of 100, 200, and 400 μg/mL, the extract of M. integrifolia with C. ficifolia inhibited cell growth by 26.57%, 35.79%, and 47.60%, respectively. The P. dulcis extract with C. ficifolia achieved inhibitions of 29.52% and 33.95% at 200 and 400 μg/mL. However, no significant reduction in cell viability was observed, suggesting a cytostatic rather than cytotoxic mechanism. These findings highlight the potential of these extracts as cell growth inhibitors in breast cancer.