Efectos del estrés por separación materna precoz en la programación metabólica

Abstract

Abstract: Maternal care plays an important role in brain maturation and the development of metabolic systems. Maternal separation is a type of early-life stress that disrupts parental buffering and whose exposure affects cognitive and metabolic development. Although recent studies have shown that stress increases individual vulnerability to psychopathologies, it remains unclear whether stress programs the metabolism to develop diseases associated with metabolic syndrome. Therefore, this study aimed to identify the influence of maternal separation stress on the development of metabolic diseases in adulthood. To this end, we reviewed recent scientific evidence linking stress with the development and progression of metabolic disorders throughout life. The results demonstrate that stress alters neuroendocrine systems, causing metabolic conditions such as insulin resistance, hyperglycemia, dyslipidemia, hypertension, gut microbiota dysbiosis, and cardiovascular disease, all of which have been associated with the development of metabolic syndrome in adulthood.