Diseño y desarrollo de una crema hidratante a base de extractos naturales

Abstract

Abstract: The objective of the present work was to develop a moisturizing cream for oily and combination skin, incorporating natural extracts of Turmeric, Rice, and Aloe vera as active ingredients. For the optimization of the formula, a 23 factorial design was applied, evaluating the interaction between the rheological modifier, emulsifiers, and oily excipients. After subjecting the mixtures to thermal stress, formulation M7 was selected as the optimal one for maintaining its physicochemical and organoleptic stability during an accelerated study of 90 days at 30°C and 40°C. The characterization of the final product resulted in an oil-in-water (O/W) emulsion with a pH of 5.52, viscosity of 6.90 Pa*s, spreadability of 1226 mm2 using 100 g of force, and an average droplet size of 3 to 12 μm. Finally, biomechanical properties in volunteers demonstrated a statistically significant increase in stratum corneum hydration without altering the skin barrier function (TEWL), thus validating the achievement of a functional and effective formula with moisturizing and antioxidant properties, which is lightweight and fast absorbing.