Diseño de una Guía Farmacéutica para el seguimiento y fortalecimiento de la adherencia terapéutica en el tratamiento con medicamentos antifímicos en Ecuador

Abstract

Abstract: Tuberculosis (TB) is a priority infectious disease for public health in Ecuador. Its epidemiological persistence is associated with poor therapeutic adherence among patients, which contributes to anti-tuberculosis treatment failure and the development of drug resistance. Given the lack of standardized tools for the pharmacotherapeutic follow-up of this population, this study aimed to design a Pharmaceutical Guide focused on monitoring and strengthening therapeutic adherence in patients with tuberculosis. Based on the evidence reviewed, the main clinical, pharmacological, and social determinants were identified, enabling the development of a guide that integrates pharmacotherapeutic validation procedures, indirect methods for assessing therapeutic adherence, and patient-centered educational strategies. The proposed guide was developed through a critical synthesis of the available scientific evidence and constitutes a technical instrument that strengthens the pharmacist s role as a key member of the healthcare team. Finally, t he guide establishes a technical foundation for future stages of piloting, implementation, evaluation, and institutional adaptation within the Ecuadorian healthcare setting.