Evaluación de la carga anticolinérgica y las interacciones farmacológicas en adultos mayores mediante escala ACB

Abstract

Abstract: This study aimed to analyze the scientific evidence regarding anticholinergic burden and drug interactions in older adults with the goal of identifying the medications most frequently implicated, the primary interactions and the associated adverse events, a literature review was conducted by searching for studies in scientific databases such as PubMed, Scopus, ScienceDirect, SciELO, LILACS and Google Scholar. Following the selection process illustrated by the PRISMA diagram with 30 studies meeting the established criteria were included in the findings demonstrated that tricyclic antidepressants, antipsychotics, firstgeneration antihistamines and antimuscarinics are the main contributors to anticholinergic burden, furthermore a consistent association was identified between high anticholinergic burden and an increased risk of cognitive decline, dementia, falls, hospitalizations and loss of functional ability, it is concluded that the systematic assessment of anticholinergic burden and the optimization of pharmacotherapy are fundamental strategies for improving treatment safety and the quality of life of older adults.