Please use this identifier to cite or link to this item: http://dspace.utpl.edu.ec/handle/123456789/19251
Title: Preparation, Characterization and Antibacterial Activity of Poly(epsilon-caprolactone) Electrospun Fibers Loaded with Amoxicillin for Controlled Release in Biomedical Applications
Authors: Malagon Aviles, O.
Cartuche Flores, L.
Vittoria, V.
Stanzione, M.
Valarezo Valdez, B.
Tammaro, L.
Keywords: electrospinning
poly(e
caprolactone)
nanofibers
amoxicillin
antibacterial activity
metadata.dc.date.available: 2012-12-01
2017-06-16T22:03:13Z
Publisher: Journal of Nanoscience and Nanotechnology
Abstract: Amoxicillin (AMOX) was successfully encapsulated at different concentrations into poly(caprolactone) (PCL) by the electrospinning technique, and mats of non-woven fibers were obtained and characterized in terms of morphology, in vitro release and antibacterial properties. The scanning electron microscopy evidenced the nanofibrous structure of the pristine PCL, composed of individual, uniform, and randomly oriented fibres with an average diameter ranging around 0.8 micron. The addition of amoxicillin at different concentrations (3, 5 and 7) did not evidence change in the fiber morphology. The release curves, for all samples, present mainly two stages: a first stage, quick as a burst, is followed by a second slow stage. The burst was analyzed as a function of amoxicillin concentration and thickness of the membranes, and values corresponding to absence of burst were individuated. In the second stage the release was found very slow extending up to months for the most concentrated sample. The antibacterial activity of the electrospun fibers was effective to inhibit in different proportions Staphylococcus aureus, Enterococcus faecalis and Escherichia coli. The properties of the filled membranes and their capability for local delivery of antibiotics make them suitable for biomedical applications.
metadata.dc.identifier.other: http://dx.doi.org/10.1166/jnn.2012.7119
URI: http://dspace.utpl.edu.ec/handle/123456789/19251
ISBN: 15334880
Other Identifiers: http://dx.doi.org/10.1166/jnn.2012.7119
Other Identifiers: http://dx.doi.org/10.1166/jnn.2012.7119
metadata.dc.language: Inglés
metadata.dc.type: Article
Appears in Collections:Artículos de revistas Científicas

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