Aislamiento de metabolitos secundarios bioactivos de Niphogeton dissecta (Benth.) J.F. Macbr. (Culantrillo del cerro)

Abstract

Abstract: The present research carried out in 2012 was based on obtaining bioactive secondary compounds or metabolites from the species Niphogeton dissecta, which was collected in the province of Loja, Saraguro canton; For which, from the ethyl acetate extract, which was the one that presented the greatest antifungal activity against the dermatophyte fungi Trichophyton mentagrophytes (Tm) and Trichophyton rubrum (Tr), column chromatography was carried out using organic solvents in different proportions, resulting in 150 fractions, of which the first fractions obtained were those evaluated against the dermatophytes already mentioned, resulting in 8 of them with antifungal activity at a concentration of 200 ug/ml using the bioautography test; of which only 8,9,13 and 14 presented an MIC of less than 250 ug/ml. The results obtained lead us to conclude that the species evaluated has the capacity to produce bioactive antifungal compounds.