Obtención, aislamiento e identificación de metabolitos secundarios de la especie vegetal Lobelia decurrens con posible potencial antitumoral

Abstract

Of Lobelia decurrens species I obtain three extracts in dissolvents in ascendant polary: hexane (Hex) Acetate etilo (AcoET) and methanol MeOH. The methanol extract presents more performance it means 7,8%. The extract AcOEt has a better porcent of inhibiton in the cell lines it means in the RKO (colon cancer), MCF-7 (cáncer de mama) D-384 (cerebral astrocynoma), PC-3 (de prostate cancer), y HCT-116 (colon cancer). The extract was made through open chromathic column and obtaining the acetate extract (AcOEt). This is an identified compound named citropten (1) in wich retention presents un 18.47of time in its fusion 145-147°C, Rf of 0.64. Also I obtain one point of fusion in the a 165-167°C mix, and 0.70 Rf whith 34.61 and 35.89 of retained time, in wich compounds I identify two compounds more α-amiryna (2) and Lupeol. Of the MeOH extract I obtain one withr cristallized compound identidied as saccharose (4) whith a fusion point of 185- 186°C, Rf of 0.69. The identified compounds were found whith espectroscopics techniques and espectroscopics like RMN, 1H, 13C in fusion point and CG/EM.