Modulación de las proteínas de la familia de p53 en células de cáncer de mama al ser expuestas al [(E) -4- (5-hidroxi-6- (3- (4-hidroxifenil) acriloil) -2-metil-2H-cromen-2-il) butan-2-ona]

Abstract

Breast cancer is defined as an abnormal growth of glandular breast cells; these cells can penetrate several healthy tissues and metastasize. In Ecuador from 2007 to 2011, the average number of new breast cancer cases is 351. It causes 20% of cancer-related deaths nationwide. Natural species play an important role in the discovery of new drugs with anti-proliferative properties. The compound, [(E)-4-(5-hydroxy-6-(3-(4-hydroxyphenyl) acryloyl)-2-methyl-2H-chromen-2-yl) butan-2-one], is a chalcone isolated from a Azorella madrepórica species and has demonstrated anti-neoplastic effects on several tumor lines, including MCF-7 breast cancer cells. The objective of this study was to determine the effects of treatment on the activation of pathways that regulate cell growth, proliferation, DNA repair, and cell death. The results indicated that this compound induced breast tumor cell death necroptosis and autophagy pathways. It also inhibited cell cycle and DNA repair. By ascertaining the molecule’s effects on breast cancer cells, specific and effective phytotherapies can be developed and applied.