Desarrollo y optimización de una loción con propiedad repelente a base de aceite esencial de Palo Santo (Bursera graveolens).

Abstract

The aim of this experimental work was to elaborate a repellent lotion whose active principle (pa) is the essential oil of holly wood, evaluating the interaction between the active principle and 7 excipients using the experimental design of binary mixtures, showing that 3 components interacts with limonene (majority compound 68% and the one owing the repellent activity). The analysis of oil and lotion was done in a GC-MS. When studying the repellent effectiveness, four concentrations were tested (0.5% - 1% - 2% - 3%); the lotion elaborated at 2% is the one that provides protection up to 80% against Aedes aegypti mosquitoes. As part of the stability studies of the product, limonene degradates more than 10% when the lotions are stored at 30 °C  2 and 40 °C  2 respectively. Additionally, microbiological and acute dermal toxicity bioassays demonstrate that the formula when tested in rats produces no side effects, and lacks pathogenic elements that could put your health in risk