Uso de AINES, como factor de prevención de cáncer gástrico

Abstract

Abstract: The role of non-steroidal anti-inflammatory drugs has been the subject of research since aspirin was shown to reduce the incidence of colorectal cancer. In spite of the strategies implemented in the prevention of gastric cancer, the worldwide prevalence and mortality of gastric cancer continues to be a cause for public health concern, especially in those countries with the highest rates, such as East Asia, Eastern Europe and South America. In the present work, a systematic review was conducted through Pubmed, Scopus and Scielo to identify the current evidence on nonsteroidal anti-inflammatory drugs compared to established gastric cancer prevention measures. The conclusions include that consumption of nonsteroidal anti-inflammatory drugs could reduce risk in low doses, on a regular and long-term basis, mainly gastric adenocarcinoma located in regions other than the cardia. Eradication of H. pylori infection has shown prevention at the same location. However, preventive measures related to lifestyle modifications have determined primary prevention of gastric cancer located in the cardia.