Evidencia de tratamiento de primera línea para dolor neuropático periférico. Una revisión bibliográfica narrativa

Abstract

Abstract: Neuropathic pain (NP) occurs as a direct result of injury or disease altering the structure and function of the somatosensory system. Objective:To review the most effective first-line pharmacological treatment for peripheral neuropathic pain. Methodology:A thorough search of articles published in databases such as Pubmed, Scielo, Cochrane was carried out, taking into account that the articles meet the inclusion criteria, resulting in 20 bibliographic sources among which we found original articles, systematic reviews, narrative reviews and international clinical guidelines. Result:The bibliographic sources found were from the last 10 years, in which it was estimated that pregabalin is the most effective drug for the treatment of neuropathic pain, based on the studies analyzed where it showed a symptomatic relief of neuropathic pain of up to 50%, making it a bearable or tolerable pain, however, there are other first line drugs such as dual antidepressants and lidocaine patches 5%, demonstrating effectivenessand with fewer side effects. Conclusion:Further well-designed studies are needed to define the best treatment. This review shows that it is necessary to individualize treatment, sometimes multimodal treatment is required in search of greater efficacy and fewer adverse effects.