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Title: | Estudios sobre derivados con base en N,N-13-dimetilamino - dehidroleucodin |
Authors: | Malagón Avilés, Omar Germán Carrillo Pardo, Jaime Eduardo |
Keywords: | Ecuador. Tesis digital. |
Issue Date: | 2023 |
Citation: | Carrillo Pardo, J. E. Malagón Avilés, O. G. (2023) Estudios sobre derivados con base en N,N-13-dimetilamino - dehidroleucodin [Tesis de Grado, Universidad Técnica Particular de Loja]. Repositorio Institucional. https://dspace.utpl.edu.ec/handle/123456789/33533 |
Abstract: | Abstract: Sesquiterpene lactones are a large group of molecules whose main function is to protect plants against predators. Initially it was established that their toxicity level was high, but through different scientific research studies it was confirmed that they could act as promising antitumor agents. studies confirmed that they could act as promising antitumor agents. In the case of dehydroleucodine, its structure contains a group called α-methylene--lactone, to which biological activity has been assigned, especially against acute myeloid leukemia. The compound has a limited solubility in water. In this work, studies were developed to modify 2ehydroleucodine at the structural level, obtaining as a result three derivatives, from which it was proposed to continue with the research on N,N-13-dimethylamino-dehydroleucodine. A methodology based on Luche's conditions was also proposed to reduce the carbonyl of position 2 of the cyclopentanone system. As a final result four compounds were obtained, of which two turned out to be N,N-13-dimethylamino-dehydroleucodine, while the third derivative due to its molecular weight was considered for future analysis, emphasizing the fourth compound it was possible to isolate 9.9 mg of: Lactol; 12-hydroxy-N,N-13-dimethylamino dehydroleucodine. |
Description: | Resumen: Las lactonas sesquiterpénicas conforman un amplio grupo de moléculas, cuya principal función es brindar protección a las plantas frente a depredadores. Inicialmente se estableció que su nivel de toxicidad era alto, pero a través de distintos estudios de investigación científica se confirmó que podían actuar como antitumorales promisorios. En el caso de dehidroleucodina, su estructura contiene un grupo llamado α-metileno--lactona, al cual se le asigna actividad biológica, especialmente contra la leucemia mieloide aguda. El compuesto cuenta con una limitada solubilidad en agua. En este trabajo se desarrollaron estudios para modificar la dehidroleucodina a nivel estructural, obteniendo como resultado tres derivados, de los cuales se planteó seguir con la investigación en N,N-13-dimetilamino dehidroleucodina. También se propuso una metodología en base a condiciones de Luche para reducir el carbonilo de la posición 2 del sistema ciclopentanona. Como resultado final se obtuvieron cuatro compuestos, de los cuales dos resultaron ser N,N-13-dimetilamino dehidroleucodina, mientras que el tercer derivado debido a su peso molecular se lo consideró para futuros análisis, enfatizando el cuarto compuesto se logró aislar 9.9 mg de: Lactol; 12- hidroxi-N,N-13-dimetilamino-dehidroleucodina. |
URI: | https://bibliotecautpl.utpl.edu.ec/cgi-bin/abnetclwo?ACC=DOSEARCH&xsqf99=133217.TITN. |
Appears in Collections: | Titulación de Ingeniería Química |
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