Diseño y desarrollo de gotas orales en solución a base de extractos naturales como coadyuvante en el tratamiento del insomnio

Abstract

Abstract: Insomnia is a very common sleep disorder in the population, it is characterized by sleep disturbance altering restful rest and affecting daytime activities, Its treatment is based on benzodiazepines, hypnotics that generate dependence and syndrome. of tolerance. The objective of the research is to develop oral drops in solution based on Valeriana officinalis L and Passiflora mollissima Khunt. L.H.Bailey as contributor to treatment of insomnia, focused on the use of ancestral medicine from phytotherapy. For Therefore, formulation and preformulation studies are carried out using a 22 factorial design and statistical analysis tools such as ANOVA and Tukey helping to choose the more stable formula. The results revealed formulation 3 as the most suitable exhibiting a fruity smell with a sweet flavor, translucent appearance free of particles and precipitates, Walnut color #723717; pH 5.83 ± 0.007, density 1.02 ± 0.000 and presence of bioactive compounds. Optimized formula meets parameters organoleptic and physical-chemical characteristics described according to the regulations, thus providing a product of quality.