La disbiosis intestinal y su relación con la enfermedad de Alzheimer

Abstract

Abstract: The intestinal microbiota plays a fundamental role in the physiology and pathology of the host, its alteration, also known as dysbiosis, is a condition associated not only with gastrointestinal disorders but also with diseases that affect other distal organs such as the central nervous system, among them Alzheimer's disease (AD). For this reason, the present work was developed with the aim of providing an update on medical-scientific advances regarding AD and its relationship with intestinal dysbiosis. For the present review, a bibliographic search was carried out in February 2022 using four biomedical databases: Medline, VHL, Cochrane and Scopus to identify primary and secondary scientific documents that provide information that facilitates the updating of this topic. The studies analyzed suggest that there is a relationship, although the etiopathogenesis of AD is not entirely clear, intestinal dysbiosis may participate in its development by increasing intestinal permeability and the consequent bacterial translocation, this would cause neuroinflammation, alterations cerebrovascular accidents and amyloid formation contributing significantly to the development of the disease.