Determinación de especifidad y sensibilidad del anticuerpo antipeptido cíclico citrulinado (anti.ccp) vs factor reumatoiede en el diagnóstico temprano de artritis reumatoidea en pacientes de la ciudad de Loja

Abstract

Abstract: The rheumatoid arthritis (RA) is a systemic autoimmune disease, poliarticular, inflammatory, chronicle that affects 1-2% of the world population characterized by multiple deformities and associated with a considerable morbidity and mortality. The unpredictable and highly varied course of the AR suggests the need of highly sensitive and specific diagnostic tests. The only laboratory indicator is the rheumatoid factor (RF), however this is not very specific and it can be found in other rheumatic disorders, infections and in healthy individuals. The antibodies ciclyc citrulinated peptides (anti-CCP) have been reported as powerful serologic indicator for the early diagnose of arthritis rheumatoid and the prognosis of the synovial tissue destruction. The main goal of our study was to determine the specificity and sensibility of the anti-CCP, in patients that were tested with the rheumatoid factor. The anti-CCP detection was carried out through ELISA and the rheumatoid factor was determined throughout agglutination in latex. The analysis of the ROC and AUC curve for both markers, demonstrated that the anti-CCP are more specific (Specificity=98.2% y Sensibility=91.9%; AUC=0.967) than that the RF (Specificity=93.3% Sensibility=79.1%; AUC=0.877). Therefore the anti-CCP are an useful and promising tool in the AR diagnosis.