Influencia del Factor de crecimiento transformante beta 1 en el desarrollo y supresión de prolactinomas. Revisión Narrativa.

Abstract

Abstract: Understanding tumorigenesis is essential. This bibliographic review has The objective is to identify the degree of involvement of the growth factor transforming beta 1 (TGFβ1) on the development and suppression of prolactinomas. 12 articles were examined: original and secondary, published in PudMed, virtual health library (VHL), Lilacs, Scopus, Tripdatabase, Web of Science and Cochrane, in the last 13 years. Studies in humans found: First, the Tumor development in prolactinoma is associated with low TGFβ1 levels and to invasiveness high, and may be a useful marker for invasion. Second, the TGFβ1 expression may not be strongly related to the pathogenesis of human prolactinoma. Third: agonist-resistant prolactinomas dopaminergic (AD) are more fibrous than those not resistant to AD. Discoveries in animals are: TGFβ1 is involved in the inhibition of prolactin (PRL) and the proliferation of prolactinomas. There is a difference between the TGFβ1 system in relation to sex. Changes in estrogen receptor alpha (ERα) do not affect the production of TGFβ1 in the MMQ cell line.