Mecanismos de muerte celular inducidos por el extracto metanólico de tallos de Grias neuberthii en células de cáncer de próstata (PC-3)

Abstract

Cancer is a genetic disorder of somatic cells that becomes the loss of the ability to: keep their differentiation, control their proliferation and regulate their death. There are several treatment alternatives aimed to fight against this disease, however, they all have strong side effects and a relatively low response rate. By the natural medicine, it is sought to implement potential phytopharmaceuticals which the main characteristic be its high selectivity, low toxicity and great therapeutic potential; Grias neuberthii is a species of the Lecythidaceae family found in the Amazon region of Ecuador and is attributed anti-inflammatory, antiparasitic, disinfectant and anti-tumor properties. Through the evaluation of phosphatidylserine distribution, it was determined that the extract of this specie is able to inhibit the growth of tumor cells in colon, lung, breast, prostate and brain cancer cell lines and also, we were able to establish that this extract, in prostate cancer cells, induces apoptosis through p73-dependent modulation that regulates p21 and Bax expression.