Estudio del polimorfismo rs1695 del gen GSTP1 en población lojana y su asociación a alteraciones metabólicas

Abstract

The genetic variations of the enzymes involved in the detoxification of cellular oxidation products may be associated with the susceptibility to develop different types of diseases, among which are diabetes mellitus type 2, obesity, hypertension, metabolic syndrome, among others. Glutathione S-transferase P (GSTP1) is an enzyme with an important role in the detoxification of certain compounds toxic to the cell; the Ile105Val polymorphism (rs1695, A / G) of the gene that encodes this enzyme is related to the decrease in enzymatic activity, and has been associated with the development of various metabolic alterations in some populations. The aim of this study is to study the Ile105Val polymorphism of GSTP1 and to evaluate its association with metabolic syndrome or related alterations in the Loja population. From the study, a frequency of 60% was determined for the G allele in the population, and there was also a significant increase in triglyceride values in male carriers of this allele (p = 0.026); When evaluating the relationship of the polymorphism with metabolic syndrome, a significant relationship was found with the disease (OR 3.018, CI 1.18-7.75) in the male sex.