Amplificación de la región LCR y L1 de HPV 16 de muestras citológicas de la ciudad de Loja

Abstract

Abstract:Cervical cancer is one of the main cancers that affect the female population worldwide, the human papillomavirus (HPV) is the main risk factor associated with this pathology. There are some HPV variants that have greater oncogenic capacity and increase the risk of triggering cervical cancer. The objective of this research is to determine the HPV-AR16 variants that are circulating in the Loja population, through amplification, sequencing and phylogenetic analysis of the L1 and LCR region of HPV-AR16. The results show that 86.7% are European variants and 13.3% are non-European variants (Asian-American). The data obtained are similar to those reported by some studies carried out in the country and in Latin America, which indicates a similar distribution pattern of variants in the Latin American population. This information contributes to knowledge of the current state of the pathology, allowing the development of health policies to reduce the prevalence of this virus in our population.