Formulación de un granulado con propiedad antioxidante en base a un extracto de mortiño (Vacinium floribundum Kunth)

Abstract

Abstract: In the present investigation, the formulation of a granulate based on an extract of mortiño (Vaccinium floribundum Kunth) was carried out as an active ingredient with antioxidant capacity; therefore it was obtained with the process of the fruit, until obtaining the dry extract by a lyophilization; previous preformulation studies were carried out with a factorial design of 2^2. A formula was obtained with 5 excipients plus the active principle and the percentage of antioxidants in the extract and in the mixtures carried out by wet granulation at three times, with the determination to establish the percentage of degradation of the same. The results were a degradation of 23.02% of the active principle at time 2; this formula was evaluated for quality control for granules. In conclusion, the development of a formula with antioxidant activity was demonstrated with ascorbic acid as a preservative and lactose as diluent. With these components, it was possible to maintain a majority percentage of antioxidant and achieve success as a food supplement in the pharmaceutical and food industry.