Desarrollo y caracterización de un gel de Anfotericina B y aceite esencial de palo santo (Bursera graveolens) con actividad antimicótica.

Abstract

Abstract: In this present study an antifungal gel whit amphotericin B 0,1% and Palo santo (Bursera graveolens) oil was elaborate. for the development of the magisterial formulation, pre-formulation and formulation studies were carried out, for the preformulation design we used a full factorial design 23 in the statistical program STATGRAPHICS, the results allowed to know the formula that presented minor effects and interactions with the other excipients and therefore these factors do not influence the effectiveness of the formulation. The formulation that was chosen contained CMC as a polymer, propylene glycol as a cosolvent, and sodium benzoate as a preservative. Likewise, an analysis was carried out using the quantitative chromatographic HPLC technique that will get to know the concentration of the drug, in addition, effectiveness tests were carried out: microbiological tests of MIC (minimum inhibitory concentration) obtaining satisfactory results. Finally, the tests were subjected to stability by a time of 4 months where the samples presented certain changes, but their values are not significant, considering their ideal results for the treatment of cutaneous candidiasis.