Evaluación del daño oxidativo ocasionado tras la exposición a plaguicidas en células prostáticas PNT2

Abstract

Abstract: Pesticides are substances commonly used in agricultural activities, such as pest and weed control, but they are also classified as a threat to the environment and public health because they can persist for long periods of time in both soil and water sources. It has been detailed that pesticides exert their harmful effects at the cellular level by altering various cellular processes and especially through oxidative stress, which is linked to various pathologies, including cancer. This research focused on determining the oxidative damage caused by pesticide exposure in PNT2 prostate cells, using commercial formulations of herbicides, insecticides, and fertilizers from the local market. No significant differences were observed in malondialdehyde concentrations in cells treated with pesticides compared to the control group. This result alludes to the activation of defense pathways such as the stimulation of the expression of antioxidant enzymes to prevent cellular damage.